Endocrine Abstracts

Several instances of RNA-mediated inheritance of phenotypic variation have been reported, among them metabolic disorders. We and others have observed that microinjection into naive fertilized mouse eggs of total sperm RNAs of obese and diabetic males maintained on high-fat diet induce the same pathological variation in the offspring. A role of noncoding RNAs is currently the prevailing hypothesis.The sperm RNA content is complex. It depends on environmen...